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The improvement was not overnight, and I am not claiming this is a magic cure

* * * * * (5) If the data needed to calculate the payment amount in the payment amount benchmark quarter described in and determined under 427.302(d)(1) are not available, CMS uses the third full calendar quarter after a drug is assigned a billing and payment code as the payment amount benchmark quarter, no earlier than the calendar quarter beginning July 1, 2021, or the third full calendar quarter after the drug's first marketed date, whichever is later

How is it Used

If you will not use the full vial within 28 days (common during the low-dose initiation phase), you have the options discussed in the waste minimization section above